THE MITOCHONDRIAL RHOMBOID PROTEASE PARL AS A TARGET FOR LYMPHOMA

摘要

The present invention relates to the field of cancer, more particularly to the field of lymphomas and even more particularly to the field of B- and T-cell tumors. The invention describes a transgenic mouse which does not produce the mitochondrial rhomboid like protease PARL. It is revealed that the phenotype of this mouse is characterized by a massive apoptosis in B- and T-cells. The invention thus relates to molecules which can bind to PARL and are capable of inducing apoptosis in B- and T-cells. The invention further relates to the use of these molecules to treat cancers of B- and T-cells, more commonly designated as lymphomas.