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TREATMENT OF PAIN WITH A COMBINATION OF AN ALPHA2 -ADRENOCEPTOR ANTAGONIST SUCH AS ATIPEMEZOLE OR FIPAMEZOIIE AND AN OPIOID RECEPTOR AGONIST, SUCH AS TRAMADOL
TREATMENT OF PAIN WITH A COMBINATION OF AN ALPHA2 -ADRENOCEPTOR ANTAGONIST SUCH AS ATIPEMEZOLE OR FIPAMEZOIIE AND AN OPIOID RECEPTOR AGONIST, SUCH AS TRAMADOL
This invention relates to use of an α2-adrenoceptor antagonist for the preparation of a medicament for treating a mammal, including human, to augment the action of a µ-opioid receptor agonist in the treatment of pain, susceptible to treatment with a µ-opioid receptor agonist, and said µ-opioid receptor agonist is a weakly efficacious µ-opioid receptor agonist or a moderately efficacious µ-opioid receptor agonist. This invention also relates to a corresponding method for the treatment or prevention of pain in a mammal, including human. This invention further relates to pharmaceutical preparations. The preparations comprise a weakly efficacious µ-opioid receptor agonist or a moderately efficacious µ-opioid receptor agonist, and a α2-adrenoceptor antagonist.
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