首页> 外国专利> METHOD FOR THE INDIVIDUALISED PROGNOSIS, RECOMMENDATION AND/OR MONITORING OF THERAPY AND/OR AFTER-CARE OF A TUMOROUS DISEASE

METHOD FOR THE INDIVIDUALISED PROGNOSIS, RECOMMENDATION AND/OR MONITORING OF THERAPY AND/OR AFTER-CARE OF A TUMOROUS DISEASE

机译:肿瘤的个体化治疗,预后和/或推荐的建议,推荐和/或监测方法

摘要

The invention relates to a method for the individualised prognosis, recommendation and/or monitoring of therapy and/or after-care of the tumorous disease of a patient. Methods of this type are necessary to obtain precise decision criteria for a specific therapy or the resumption of a therapy. According to the invention: a first genome profile or expression profile of a first sample containing tumorous tissue is detected at the time of the diagnosis of the tumour, said profile containing the genome status or expression status of a first plurality of human genes; the genome status or expression status is stored for the respective patient for an individual selection of human genes from a plurality of detected genes; and an additional genome profile or expression profile of a second sample containing lymph node tissue, bone marrow and/or bodily fluid is detected at a later point for the genes of the individual selection, said profile being compared with the first genome profile or expression profile. A recommendation of therapy, or a prognosis or therapy evaluation is then carried out as a result of said comparison.
机译:本发明涉及一种用于对患者的肿瘤疾病的治疗和/或后续治疗进行个体化的预后,推荐和/或监测的方法。这种类型的方法对于获得针对特定治疗或恢复治疗的精确决策标准是必要的。根据本发明:在诊断肿瘤时检测包含肿瘤组织的第一样品的第一基因组图谱或表达图谱,所述图谱包含第一批多个人类基因的基因组状态或表达状态。为各个患者存储基因组状态或表达状态,以从多个检测到的基因中单独选择人类基因;并在稍后的时间点检测包含个体淋巴结组织,骨髓和/或体液的第二个样品的其他基因组图谱或表达谱,将其与第一基因组图谱或表达谱进行比较。作为所述比较的结果,然后进行治疗的推荐,或者预后或治疗的评估。

著录项

  • 公开/公告号WO2007060002A2

    专利类型

  • 公开/公告日2007-05-31

    原文格式PDF

  • 申请/专利权人 VOGT ULF;BRANDT BURKHARD;

    申请/专利号WO2006EP11308

  • 发明设计人 VOGT ULF;BRANDT BURKHARD;

    申请日2006-11-24

  • 分类号C12Q1/68;

  • 国家 WO

  • 入库时间 2022-08-21 20:49:35

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