A sewing machine with a needle thread cassette, wherein a cassette mount (3) is reduced in size. The cassette mount (3) including a thread take-up lever travel region is formed in the form of a vertical groove in the arm head of the sewing machine. A needle thread cassette (2) having a thread bobbin (62) vertically received therein is removably mounted on the cassette mount (3) vertically from above. With a thread take-up lever (25) stopped in a position corresponding to a needle top stop position, the needle thread cassette (2) is mounted on the cassette mount (3), whereby the thread is engaged with the thread guard of the thread take-up lever (25) and a thread tension regulator (9).
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