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METHODS FOR IDENTIFYING LIGANDS USING WATERLOGSY NMR
METHODS FOR IDENTIFYING LIGANDS USING WATERLOGSY NMR
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机译:利用水浸核磁共振法鉴定配体的方法
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摘要
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a test sample comprising at least one test compound; collecting a WaterLOGSY nuclear magnetic resonance spectrum of the reference compound in the presence of the test sample and the target molecule; and comparing the WaterLOGSY spectra to determine if at least one test compound interacts with the target molecule with a binding affinity tighter than that of the reference compound.
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