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Methods for determining the relationship between hybridization signal of probes and target DNA copy number
Methods for determining the relationship between hybridization signal of probes and target DNA copy number
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机译:确定探针杂交信号与靶DNA拷贝数之间关系的方法
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摘要
Methods for evaluating surface-bound polynucleotides are provided. Specifically, the methods involve contacting an array of surface-bound polynucleotides with a population of labeled nucleic acids made from a non-naturally occurring composition of chromosomes, and evaluating binding of the labeled nucleic acids to a surface-bound polynucleotide. The methods may be used, for example, to screen for surface bound polynucleotides that have desirable binding characteristics, e.g., suitability for use in array-based comparative genomic hybridization assays. Kits and computer programming for use in practising the subject methods are also provided.
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