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DRUG CANDIDATE SELECTION BY HYDROGEN EXCHANGE CHARACTERIZATION OF LIGAND-INDUCED RECEPTOR CONFORMATION
DRUG CANDIDATE SELECTION BY HYDROGEN EXCHANGE CHARACTERIZATION OF LIGAND-INDUCED RECEPTOR CONFORMATION
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机译:配体诱导的受体构象的氢交换特征选择候选药物
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摘要
A method is provided of selecting a compound that (a) binds a receptor, and (b) on binding the receptor, induces a perturbation in the conformation of the receptor, which conformational perturbation is correlated with a particular pharmacological activity.
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