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DERIVATIVES OF PNEUMOCOCCAL CHOLINE BINDING PROTEINS FOR VACCINES
DERIVATIVES OF PNEUMOCOCCAL CHOLINE BINDING PROTEINS FOR VACCINES
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机译:疫苗的肺炎球菌胆碱结合蛋白的衍生物
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摘要
The present invention provides bacterial immunogenic agents for adminstration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species.
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