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Microarray comprising probes for drug-resistant hepatitis B virus detection, quality control and negative control, and Method for detecting drug-resistant hepatitis B virus using the same
Microarray comprising probes for drug-resistant hepatitis B virus detection, quality control and negative control, and Method for detecting drug-resistant hepatitis B virus using the same
The invention target probes (target probes) and QC probes for quality control of the production process and the hybridization process of the microarray (QC probes), and one or more of the wild-type and for detecting a drug-resistant hepatitis B virus (HBV) determination of mixing and whether the degree of mutation types, non-specific cross-background due to the hybridization reaction measurement, or homozygous (homozygote) and heterozygous (heterozygote) negative control probe microarray produced by mixing a (negative control probes) for distinguishing between and using this drug-resistant HBV detection of the virus, to a method of performing the quality control and more than one type of micro-array and whether the degree of mixed crystal and positive and false positive probes at the same time determined for each. ; Microarrays according to the present invention has drug-resistant hepatitis B virus detection method includes the target probes and QC probes and negative control probes for drug-resistant hepatitis B virus detection, the manufacturing process and the hybridization process of the microarray quality control and a more than one wild-type and not only possible to distinguish the mutant type of mixing and whether the degree, positive and false-positive determination on each of the probe due to the background measurement by the non-specific cross-hybridization, or homozygous (homozygote) and heterozygous (heterozygote), by them as a set of mounting a plurality of sets on one of the support by the first session of the experiment at the same time a plurality of drug resistance from a number of sample hepatitis B virus detection, mixing, and whether a mixture of quality control and the wild-type and mutant degree with each probe this decision is a positive and false-positive for the rapid and accurate diagnosis and possible measures.
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