-1 An RNA aptamer that binds to the -catenin interaction domain of TCF-1 protein and the uses thereof

摘要

FIELD OF THE INVENTION The present invention relates to RNA aptamers and uses thereof, and more particularly to RNA aptamers and their use as therapeutic agents for cell proliferative diseases, specifically binding to the N-terminus of TCF-1 interacting with beta-catenin. It is about. The RNA aptamer of the present invention can be effectively used to develop a cell proliferative disease drug by effectively interfering with the formation of TCF-1 and beta-catenin complex.; RNA Aptamer, TCF-1, Beta-Catenin