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DEVELOPMENT AND USE OF A NEW ORTHOTOPIC GENETICALLY TRACTABLE NON-HUMAN ANIMAL MODEL FOR LIVER CANCER

机译:肝癌新的正交基因可追踪非人类动物模型的开发和应用

摘要

This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.
机译:本发明提供了用于肝细胞癌的遗传可治疗的原位非人动物模型。该模型尤其可用于了解肝癌的分子机制,了解导致化学耐药性或不良预后的遗传改变,以及用于识别和评估针对肝细胞癌的新疗法。本发明的肝癌模型是通过改变肝细胞以增加癌基因表达,降低肿瘤抑制基因表达或两者并通过将所得肝细胞移植到非人类动物体内而制成的。

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