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DEVELOPMENT AND USE OF A NEW ORTHOTOPIC GENETICALLY TRACTABLE NON-HUMAN ANIMAL MODEL FOR LIVER CANCER
DEVELOPMENT AND USE OF A NEW ORTHOTOPIC GENETICALLY TRACTABLE NON-HUMAN ANIMAL MODEL FOR LIVER CANCER
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机译:肝癌新的正交基因可追踪非人类动物模型的开发和应用
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摘要
This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.
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