SITE-SPECIFIC IMMUNIZATION IN ORDER TO ESTABLISH ANTIBODIES WITH SPECIFICITY FOR THE E7 ONCOPROTEIN OF HIGH-RISK HPVS

摘要

The present invention relates to a method for establishment of antibodies with specificity for high-risk HPVs compared to immunization using the whole antigen of high-risk HPVs, wherein the method includes an exclusion of evolutionary conserved motifs as well as regions with high similarity to E7 proteins of low-risk HPVs, as well as thus obtained antibodies.