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METHOD FOR SELECTIVE SEPARATION OF TARGET BIO-MOLECULES THROUGH DIELECTRIC MAKE-UP EITHER TARGET BIO-MOLECULES OR THE OTHERS USING NANOPARTICLES BY DIELECTROPHORESIS
METHOD FOR SELECTIVE SEPARATION OF TARGET BIO-MOLECULES THROUGH DIELECTRIC MAKE-UP EITHER TARGET BIO-MOLECULES OR THE OTHERS USING NANOPARTICLES BY DIELECTROPHORESIS
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机译:通过介电选择性地通过介电修饰目标生物分子或其他目标分子分离目标生物分子的方法
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摘要
A method for selectively separating a target bio-molecule is provided to significantly increase the separation efficiency of the target bio-molecule with decreasing the influence on the activity of the target bio-molecule by doping nano-particles into either one of the target bio-molecule or the remaining bio-molecule, thereby significantly improving the dielectric property of a bio-molecule doped by the nano-particles. The method comprises the steps of: (a) preparing a fluid sample where a plurality of bio-molecules including target bio-molecule is dispersed in a carrier medium; (b) selectively treating a plurality of nano-particles so as to selectively dope one of the target bio-molecule dispersed in the fluid sample or the remaining bio-molecules; (c) contacting the fluid sample with the treated plurality of nano-particles to dope the plurality of the nano-particles into the bio-molecule; (d) applying an electric field which is spatially non-uniformed to the nano-particles doped bio-molecule; and (e) dividing the bio-molecule into the target bio-molecule and the remaining bio-molecule using improved dielectric property of the nano-particles doped bio-molecule under the applied non-uniformed electric field. In the method, the plurality of bio-molecules is procaryotic cell or eukaryotic cell, and the size of the nano-particles is 1-100 nanometers.
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