THE PROTEIN NANO-PARTICLES THAT ARE FORMED BY FUSING PROBE PROTEIN TO TEMPLATE PROTEIN WITH HIGH AFFINITY FOR DNAK

摘要

The present invention relates to a nanoparticle in which a template protein including a motif having a high affinity with DnaK and a probe protein are fused to a probe protein such as an antigen, an antibody, a cell receptor, or an enzyme. When the fusion protein of the present invention is expressed in E. coli, the water solubility is increased, and in particular, when the template protein is a ferritin heavy chain, the particles are spherical so that the protein probe is exposed on the surface, and thus may be useful for the development of high sensitivity protein chips.;Ferritin, Protein Nanoparticles, Protein Chips