A SUSPENSION COMPRISING AN ACTIVE PRINCIPLE, A SUSPENDING VEHICLE, A DENSITY-MODIFYING SOLID WITH AN INCREASED PHYSICAL STABILITY

摘要

Density-matching is used to provide suspending vehicles, pharmaceutical suspensions, dosage forms, and kits as well as methods of making and using the vehicles, suspensions and dosage forms. Pharmaceutical suspensions comprising a pharmaceutically active agent having an active agent density, rhoA, and a suspending vehicle having a suspending vehicle density, rhosv; wherein the suspending vehicle density, rhosv is substantially equal to the active agent density, rhoA, are provided. Suspending vehicles comprise at least one suspending agent. The suspending vehicles can further comprise at least one density-modifying solid in such a combination with the suspending agent as to create a suspending vehicle that has a density that substantially matches the density of a desired drug particle or combination of drug particles. Pharmaceutical suspensions that remain homogenous during prolonged storage can be obtained.