SELF-ASSEMBLY NANO-COMPOSITES COMPRISING HYDROPHILIC BIOACTIVE PEPTIDES AND HYDROPHOBIC MATERIALS

摘要

A self-assembly nano structure comprising hydrophilic bioactive peptides and hydrophobic materials is provided to promote adhesion, proliferation and differentiation of cells in the damaged tissue by adhering the self-assembly nano structure on the surface of a biological material and permeating the bioactive peptides into the living body while the peptides maintains structural stability, and maximize the tissue regeneration restoring efficiency. The self-assembly nano structure comprises a hydrophilic bioactive peptide selected from a cell adhesion-inducing peptide, a tissue growth factor-derived peptide or a cell permeation peptide and a hydrophobic material selected from a hydrophobic hydrocarbon, a hydrophobic polymer, a hydrophobic peptide and silane, and is prepared by applying the more than CMC(critical micelle concentration) of hydrophilic bioactive peptide and hydrophobic material to the water system, wherein the hydrophilic bioactive peptide and hydrophobic material are linked by an amide bonding; and the hydrophobic material is modified by a carboxyl group or an amine group for amide bonding.