Biomarker proteins for diagnosing the exposure to PAH

摘要

The present invention relates to the development of a protein that can be used as a biomarker when exposed to environmentally hazardous polycyclic aromatic hydrocarbons (PAH), more specifically in the blood of humans exposed to PAHbenzene, but not in normal blood The present invention relates to a biomarker protein that is expressed more in the blood of humans exposed to PAH than in normal human blood and a diagnostic kit for PAH exposure using the same.;According to the present invention, not only the level of PAH exposure of the operator can be measured from a small amount of blood, which is easy to obtain, but also the physiological state of the PAH exposed person can be grasped to the degree of contamination. In addition, monoclonal antibodies prepared on the basis of the biomarker protein of the present invention can be used in immunoassay kits (ELISA, antibody coated tube test, lateral-flow test, potable biosensor), and also exhibit higher specificity and sensitivity. It can also be used for the development of protein chips having various hardly degradable contaminant detection spectra through the development of antibodies.