ENDO-BIOPOLYMER ISOLATED FROM SUBMERGED MYCELIAL CULTURE OF PHOLIOTA NAMEKO INCREASING IMMUNO-STIMULATING ACTIVITY

摘要

Provided is an intracellular biopolymer isolated from a submerged-liquid culture of Pholiota nameko, which is effective in increasing anti-complement, macrophages, and spleen cells and is useful for immunostimulating pharmaceutical compositions. The Pholiota nameko-derived intracellular biopolymer having an increase effect of anti-complement, macrophages, and spleen cells is separated from a submerged-liquid culture of Pholiota nameko. The intracellular biopolymer consists of a fraction comprising 79.6% of saccharide containing mannose and glucose having a molecular weight of 1000kDa as main materials and 20.4% of protein containing glycine and lysine as main materials, and a fraction comprising 86.9% of saccharide containing mannose, galactose, and glucose having a molecular weight of 3.1kDa as main materials and 13.1% of protein containing aspartic acid, threonine, glutamic acid, and glycine as main materials.