Endo-polymer and exo-polymer obtained from submerged mycelial culture of Cordyceps militaris increasing immuno-modulating activities and optimum culture conditions for producing the same

摘要

The invention japonica ( Cordyceps militaris ) mycelium liquid for intracellular polysaccharide obtained from the culture enhanced immune activity (endo-polymer) and the in vitro bacterial polysaccharides (exo-polymer) and the production of immune composition containing as an active ingredient, the optimum conditions and it as optimum pH, temperature, stirring rate and inoculum size of mycelia, and fungi in vitro production of Cordyceps polysaccharide were 6.0, 25 about, 150 rpm, was 4%, the optimum carbon and nitrogen sources are sucrose 20g / L (sucrose) and yeasts extract (yeast extract) 4g / L. The cells in vitro bacterial polysaccharides and polysaccharide production this time also be useful as a pharmaceutical composition or health functional composition as a composition for enhancing the immune activity of the active ingredient, so it is effective to increase the anti-complement activity and macrophage lysosomal enzyme activity is an excellent invention that can be.