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Method for Preparing a Useful Secondary Metabolite by Effective Elimination of Biological By-Products
Method for Preparing a Useful Secondary Metabolite by Effective Elimination of Biological By-Products
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机译:通过有效消除生物副产物制备有用的次级代谢产物的方法
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摘要
The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more particularly, in order to efficiently eliminate biological by-products formed during the culture of Sorangium cellulosum, the present invention relates to a method for producing epothilones comprising that a cation exchange resin is added to said culture medium or said culture broth is recirculated through a column charged with a cation exchange resin. According to the present invention, the effective elimination of by-products formed during the culture of Sorangium cellulosum enhances growth rate of the microorganism as well as dramatically improves productivity of epothilones, a useful secondary metabolite
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