-4-1 Pharmaceutical composition comprising the anti-4-1BB antibody for preventing and treating rheumatoid arthritis

摘要

The present invention relates to a composition for preventing and treating rheumatoid arthritis, and more particularly, to an arthritis containing an anti-4-1BB antibody as an active ingredient that induces an increase in CD11c ⁺ CD8 ⁺ T cells and CD4 ⁺ T cell inhibition. It relates to a pharmaceutical composition for prophylaxis and treatment. The composition of the present invention can significantly improve the symptoms of advanced, inflammatory or autoimmune arthritis by inducing antigen-specific immunosuppression without being toxic to the overall immune response, and thus can be applied to the prevention or treatment of arthritis without side effects.;Arthritis, 4-1BB, immunosuppressive