CELL-BASED HIGH-THROUGHPUT SCREENING METHOD OF T-TYPE CALCIUM CHANNEL BLOCKERS

摘要

The present invention provides a high efficiency of α1G T-type or α1H T-type calcium channel blockers using fluorescence imaging HTS measurement, which is useful for shortening the development time of T-type calcium channel blockers in neurons. High-throughput screening (HTS). T-type calcium channel blockers are useful for the treatment and prevention of many diseases such as angina, high blood pressure, myocardial diseases, pain, and epilepsy by inhibiting calcium channels in cell membranes.;T-type calcium channel, fluorescent calcium imaging, myocardial disease, epilepsy, pain, patch clamp