首页> 外国专利> PREPARATION OF PH-RESPONSIVE POLYMER-LIPOSOME COMPLEXES AND THE COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING THE SAME

PREPARATION OF PH-RESPONSIVE POLYMER-LIPOSOME COMPLEXES AND THE COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING THE SAME

机译:PH响应型聚合物-脂质体复合物的制备及皮肤外用药的组成

摘要

The present invention relates to the preparation of a polymer-liposomal nanocomposite using an acidity sensitive polymer and an external composition for skin containing the same, and specifically, using an acidity sensitive polymer composed of methacrylic acid and n-alkyl methacrylate, lipids and cholesterol. As a manufactured polymer-liposomal nanocomposite or nanoemulsion, it has a sensitive sensitivity to changes in acidity, which effectively releases physiologically active ingredients incorporated into the inner phase in vivo, thereby enhancing the effect as a transporter and preparing based on conventional lipids. The present invention relates to a polymer-lipid-based drug carrier and an external dermal composition designed to be more stably present in an aqueous solution and various salt-containing formulations and skin external preparation compositions and cosmetic formulations.;Acidity Sensitive Polymers, Polymer-Liposome Nanocomposites, Liposomes, Nanoemulsions, Formulation Stability
机译:本发明涉及使用酸度敏感性聚合物和包含该酸度敏感性聚合物的皮肤外部组合物,特别是使用由甲基丙烯酸和甲基丙烯酸正烷基酯,脂质和胆固醇组成的酸度敏感性聚合物制备聚合物-脂质体纳米复合材料。作为制成的聚合物-脂质体纳米复合材料或纳米乳剂,它对酸度的变化具有敏感的敏感性,可有效释放体内结合到内相中的生理活性成分,从而增强了作为转运蛋白的功效,并基于常规脂质制备而成。本发明涉及基于聚合物脂质的药物载体和外部皮肤组合物,其被设计为更稳定地存在于水溶液和各种含盐制剂以及皮肤外部制剂组合物和化妆品制剂中。酸敏感性聚合物,聚合物-脂质体纳米复合材料,脂质体,纳米乳剂,制剂稳定性

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