PREPARATION OF PH-RESPONSIVE POLYMER-LIPOSOME COMPLEXES AND THE COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING THE SAME

摘要

The present invention relates to the preparation of a polymer-liposomal nanocomposite using an acidity sensitive polymer and an external composition for skin containing the same, and specifically, using an acidity sensitive polymer composed of methacrylic acid and n-alkyl methacrylate, lipids and cholesterol. As a manufactured polymer-liposomal nanocomposite or nanoemulsion, it has a sensitive sensitivity to changes in acidity, which effectively releases physiologically active ingredients incorporated into the inner phase in vivo, thereby enhancing the effect as a transporter and preparing based on conventional lipids. The present invention relates to a polymer-lipid-based drug carrier and an external dermal composition designed to be more stably present in an aqueous solution and various salt-containing formulations and skin external preparation compositions and cosmetic formulations.;Acidity Sensitive Polymers, Polymer-Liposome Nanocomposites, Liposomes, Nanoemulsions, Formulation Stability