Synthesis and characterization of new antifolate having a furo2,3-dpyrimidine derivatives

摘要

The invention TiO a p- group of para- amino acid to synthesize a novel anticancer benzo (S) group by introducing a sand Meyer reaction to obtain a substituted compound (3) , in which ethanol NaBH ₄ in the presence of furo pyrimidine derivatives (2) is reacted with the novel compounds program for interrogating ripening Acid derivative (4) and DMF ( dimethylformamide) under the presence of DCC or DEPC ( diethyl phosphorothioate - cyano your date ), the use -up was reacted with diethyl L- glutamate obtain a compound of ester of formula ( 5) , re = S ⁺ -CH ₃ and the reaction was hydrolyzed as necessary to obtain the compound of free acid form of the formula (I).