METHOD FOR STABILIZING THE SECONDARY STRUCTURE OF SYNTHETIC PEPTIDES USING N- and C-terminal modifications

摘要

1.method of stabilization of the secondary structure of synthetic peptides by u043du0435u043au043eu0432u0430u043bu0435u043du0442u043du043eu0433u043e u0432u0437u0430u0438u043cu043eu0434u0435u0439u0441u0442u0432u0438u00a0 than some of the more hydrophobic hydrocarbons or their frames between a however, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 that hydrophobic hydrocarbons or their algal mat are at opposite ends of the n and c, or in the immediate vicinity ofwith the hydrophobic hydrocarbons or their algal mat also u043du0435u043au043eu0432u0430u043bu0435u043du0442u043du043e u0441u0432u00a0u0437u044bu0432u0430u044eu0442 with u0433u0438u0434u0440u043eu0444u043eu0431u043du044bu043c host.;2. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that the hydrophobic hydrocarbons or their algal mat u043au043eu0432u0430u043bu0435u043du0442u043du043e u0441u0432u00a0u0437u044bu0432u0430u044eu0442 with u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du044bu043cu0438 active groups u043fu0435u043fu0442u0438u0434u0430, u0441u043eu0434u0435u0440u0436u0430u0449u0438u043cu0438u0441u00a0 at its opposite ends of n and with, or in close proximity to them.;3. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 2, so that the u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du044bu043cu0438 u043fu0435u043fu0442u0438u0434u0430 active groups, which u0441u0432u00a0u0437u044bu0432u0430u044eu0442 hydrocarbons or their algal mat, u00a0u0432u043bu00a0u044eu0442u0441u00a0 u043au0430u0440u0431u043eu043au0441u0438u043bu044cu043du044bu0435 group you that.;2. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 2, so that the u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du044bu043cu0438 u043fu0435u043fu0442u0438u0434u0430 active groups, which u0441u0432u00a0u0437u044bu0432u0430u044eu0442 hydrocarbons or their algal mat, u00a0u0432u043bu00a0u044eu0442u0441u00a0 u0430u043cu0438u0434u043du044bu0435 group.;3. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 2, so that the u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du044bu043cu0438 u043fu0435u043fu0442u0438u0434u0430 active groups, which u0441u0432u00a0u0437u044bu0432u0430u044eu0442 hydrocarbons or their algal mat, u00a0u0432u043bu00a0u044eu0442u0441u00a0 u0442u0438u043eu043bu043eu0432u044bu0435 group.;4. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that a carrier made of u0433u0438u0434u0440u043eu0444u043eu0431u043du043eu0433u043e polymer.;5. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that a u00a0u0432u043bu00a0u0435u0442u0441u00a0 u0432u044bu0441u043eu043au043eu043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0430u00a0 structure of u0430u043cu0444u0438u043fu0430u0442u0438u0447u0435u0441u043au0438u0445 molecules.;6. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that the hydrocarbons or their algal mat u00a0u0432u043bu00a0u044eu0442u0441u00a0 u0430u043bu0438u0444u0430u0442u0438u0447u0435u0441u043au0438u043cu0438u043c hydrocarbons.;7. method for u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 1, so that the hydrocarbons or their algal mat u00a0u0432u043bu00a0u044eu0442u0441u00a0 aromatic hydrocarbons.