Monoclonal antibodies to influenza A and apparatus for immunoassay using an antibody

摘要

1. u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody to influenza virus type a or u0430u043du0442u0438u0433u0435u043du0441u0432u00a0u0437u044bu0432u0430u044eu0449u0438u0439 fragment, which reacts with the antigen antibody u043du0443u043au043bu0435u043eu043fu0440u043eu0442u0435u0438u043du043eu043c and influenza virus and with u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du0443u044e of from 55 to 70 u043au0434u0430 u043au0434u0430 and hardly reacts with the influenza antigen antibody type.;2. u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody or its fragment on u0430u043du0442u0438u0433u0435u043du0441u0432u00a0u0437u044bu0432u0430u044eu0449u0438u0439 1, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 because it interacts with the u044du043fu0438u0442u043eu043fu043eu043c, u0438u043cu0435u044eu0449u0438u043cu0441u00a0 on the section between 59th and 130. amin u043eu043au0438u0441u043bu043eu0442u0430u043cu0438 u043du0443u043au043bu0435u043eu043fu0440u043eu0442u0435u0438u043du0430 influenza virus type a.;3. u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody or its fragment u0430u043du0442u0438u0433u0435u043du0441u0432u00a0u0437u044bu0432u0430u044eu0449u0438u0439 on 1 or 2, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 because it enters the reaction of antigen antibody to each of the u043fu043eu0434u0442u0438u043fu043eu0432 virus and the flu.;4. u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody or its fragment u0430u043du0442u0438u0433u0435u043du0441u0432u00a0u0437u044bu0432u0430u044eu0449u0438u0439 on p.u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 1, so that it is received by u0433u0438u0431u0440u0438u0434u043eu043cu044b FVA2 - 3, deposited under the inventory number FERM pl - 10066, u0433u0438u0431u0440u0438u0434u043eu043cu044b FVA2 6 deposited under the inventory number om FERM pl - 10067 or u0433u0438u0431u0440u0438u0434u043eu043cu044b FVA2 11 deposited under the inventory number FERM pl - 10068, which were deposited in a depository in accordance with the u0431u0443u0434u0430u043fu0435u0448u0442u0441 international kim agreement.;5.the device u0434u043bu00a0 immunological analysis containing zone of the scarred reagent containing an antibody to the virus u043cu0435u0447u0435u043du043eu0435 influenza type a, the u043du0430u043du0435u0441u0435u043du0438u00a0 u043eu0431u0440u0430u0437u0446 a zone of u043fu0440u043eu00a0u0432u0438u0442u0435u043bu00a0, u043fu043eu0433u043bu043eu0449u0435u043du0438u00a0 u043fu0440u043eu00a0u0432u0438u0442u0435u043bu00a0 zone and zone u0434u0435u0442u0435u043au0442u0438u0440u043eu0432u0430u043du0438u00a0 influenza virus type a, in which an antibody to influenza virus type a u0438u043cu043cu043eu0431u0438u043bu0438u0437u043eu0432u0430u043du043e in matri u043au0441u0435 and asked to u043cu0430u0442u0440u0438u043au0441u0435 zone, and at leastone of the following is u043cu0435u0447u0435u043du043eu0435 antibody to influenza virus type a and antibody to influenza virus type a, u0438u043cu043cu043eu0431u0438u043bu0438u0437u043eu0432u0430u043du043du043eu0435 zone u0434u0435u0442u0435u043au0442u0438u0440u043eu0432u0430u043du0438u00a0, u00a0u0432u043bu00a0u0435u0442u0441u00a0 u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du044bu043c ant u0438u0442u0435u043bu043eu043c on any of the u043fu043f.1 - 4.;6. the device u0434u043bu00a0 immunological analysis on p.5, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0 that additionally contains u043cu0435u0447u0435u043du043eu0435 antibody to influenza virus type b in the zone of the scarred reagent, and the u0434u0435u0442u0435u043au0442u0438u0440u043eu0432u0430u043du0438u00a0 influenza virus type b, in which the roy u0438u043cu043cu043eu0431u0438u043bu0438u0437u043eu0432u0430u043du043e antibody to influenza virus type b, with a u0434u0435u0442u0435u043au0442u0438u0440u043eu0432u0430u043du0438u00a0 influenza virus type is located near the zone u0434u0435u0442u0435u043au0442u0438u0440u043eu0432u0430u043du0438u00a0 influenza virus type a, b which u0438u043cu043cu043eu0431u0438u043bu0438u0437u043eu0432u0430u043du043e antibody to influenza virus type a.;7. the device u0434u043bu00a0 immunological analysis on clause 5 or 6, u043eu0442u043bu0438u0447u0430u044eu0449u0435u0435u0441u00a0, label u00a0u0432u043bu00a0u0435u0442u0441u00a0 enzyme, and the device contains a substrate u0434u043bu00a0 this enzyme in the ol u043eu00a0u0432u0438u0442u0435u043bu00a0 and / or in the vicinity of the zone of u043fu0440u043eu00a0u0432u0438u0442u0435u043bu00a0.