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Biodegradable Polymer Ligand Conjugates and Their Use for Isolation of Cell Subpopulations and for Cryopreservation, Culopreservation, Cultivation and Cell Transplantation
Biodegradable Polymer Ligand Conjugates and Their Use for Isolation of Cell Subpopulations and for Cryopreservation, Culopreservation, Cultivation and Cell Transplantation
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机译:可生物降解的聚合物配体结合物及其在分离细胞亚群以及冷冻保存,冷冻保存,培养和细胞移植中的用途
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摘要
The invention discloses a biodegradable particle-cell composition having at least one biodegradable particle, at least one receptive group covalently linked thereto, and a cell anchored thereto. The particle can be polylactide, a polylactide-lysine copolymer, polylactide-lysine-polyethylene glycol copolymer, starch, or collagen. The receptive group can be an antibody, a fragment of an antibody, an avidin, a streptavidin, or a biotin moiety. Moreover, the particle can also have extracellular matrix components other than collagen. The particle-cell compositions can be used for selection of cells from a population, for cell culture of anchorage-dependent cells, for cryopreservation of anchorage-dependent cells, and for transplantation as a cell therapy.
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