FIELD: organic chemistry, medicine, medicinal biochemistry, pharmacy.;SUBSTANCE: invention relates to diaryl compounds with a bridge bond of the general formula (Ia) or their pharmaceutically acceptable salts: R1O2C-CRaRb-Y-Ar1-X-Ar2-Z1-Z2-Ar3 (Ia) wherein X means -S(O)m; Y means oxygen atom (O); Z1 and Z2 are chosen independently from group including O, -(CR'R'')n and -N(R''); Ar1 and Ar2 mean independently naphthyl or phenyl optionally substituted with alkyl or halogen atom; Ar3 means phenyl substituted with trifluoromethyl group; R1 means hydrogen atom; Ra and Rb mean hydrogen atom; each among R' and R'' means hydrogen atom; m means a whole number from 0 to 2; n means a whole number from 1 to 2. Compounds proposed by the present invention can be used in treatment of metabolism disorder. Also, invention describes a pharmaceutical composition and a method for enhancing the HDL cholesterol level.;EFFECT: valuable medicinal properties of compounds.;33 cl, 2 dwg, 9 tbl, 30 ex
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机译：技术领域：本发明涉及具有通式（Ia）的桥键的二芳基化合物或其药学上可接受的盐：R 1 O 2 C-CR a R b -Y-Ar 1 -X-Ar 2 - Z 1 -Z 2 -Ar 3 （Ia）其中X表示-S（O） m ; Y表示氧原子（O）; Z 1 和Z 2 从包括O，-（CR'R''） n 和-N（R''的组中独立选择）; Ar 1 和Ar 2 分别独立地是指任选被烷基或卤素原子取代的萘基或苯基; Ar 3 表示被三氟甲基取代的苯基; R 1 表示氢原子; R a 和R b 表示氢原子; R’和R”中的每一个表示氢原子; m表示从0到2的整数; n是1〜2的整数。本发明提出的化合物可以用于代谢紊乱的治疗。此外，本发明还描述了用于提高HDL胆固醇水平的药物组合物和方法。效果：化合物的有价值的药用性质; 33 cl，2 dwg，9 tbl，30 ex
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