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METHODS FOR MEASUREMENT OF DISSOLVING RATE OF ANALYZED SUBSTANCE IN NONAQUEOUS LIQUID COMPOSITION
METHODS FOR MEASUREMENT OF DISSOLVING RATE OF ANALYZED SUBSTANCE IN NONAQUEOUS LIQUID COMPOSITION
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机译:非液体组成中分析物质溶解速率的测定方法
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摘要
FIELD: analytical measurements, pharmacy.;SUBSTANCE: method involves using a substance representing a pharmaceutically active component in a medicinal formulation characterized by sustained releasing preferably. Method involves carrying out the following procedures: (1) contacting a diluted nonaqueous composition containing analyzed substance and nonaqueous base, for example, wax or fat with an aqueous dissolving medium for predetermined time, and (ii) measurement of analyzed substance amount in aqueous dissolving medium. Invention provides enhancing precision and safety in assay of dissolving rate of analyzed substance.;EFFECT: improved assay method.;34 cl, 8 dwg, 3 tbl
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