METHOD FOR PRODUCTION OF SYNTHETIC PERFLUOROCARBON BLOOD SUBSTITUTING COMPOSITIONS AND OTHER MEDIA BASED ON PERFLUOROCARBON EMULSIONS

摘要

FIELD: organic chemistry, in particular method for production of perfluorocarbon emulsion capable of oxygen transferring.;SUBSTANCE: claimed method includes providing of perfluorocarbon emulsion by blending of total amount of perfluorocarbons with emulsifier such as proxanole-268 (or phospholipids) and multiple mixture homogenizing in high pressure homogenizer. Said perfluorocarbon emulsion is obtained by stream-droplet passing of multicomponent perfluorocarbon mixture trough subsequently arranged main and additional (second) homogenizer circuits and buffer volume for pressure compensation arranged between these circuits, wherein abovementioned multicomponent perfluorocarbon mixture contains two, three, or four perfluorocarbons in specific ratio. Then mixture is concentrated to produce perfluoroorganic compounds (PFOC) from 1 to 100 %, emulsified with proxanole-268 or phospholipid solution under pressure in both homogenizer circuits of 20-1500 atm and at cooling temperature of +15-+60°C followed by addition of electrolytes into obtained perfluorocarbon emulsion to produce finished therapeutical form.;EFFECT: perfluorocarbon emulsions with increased PFOC concentration, decreased number of emulsifying cycles.;5 ex, 1 dwg