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Preparation of organometallic compound, useful e.g. in electrophilic substitution reactions, comprises reacting an organic compound with an metal-containing compound in the presence of a lithium compound and a metal
Preparation of organometallic compound, useful e.g. in electrophilic substitution reactions, comprises reacting an organic compound with an metal-containing compound in the presence of a lithium compound and a metal
Preparation of organometallic compound (II) comprises reacting an organic compound (III) with a metal (M 3)-containing compound in the presence of a lithium compound (IV) and a metal (M 2). Preparation of organometallic compound (II) of formula R 1 m-M 3-T nzLiX comprises reacting an organic compound (III) of formula R 1-A with a metal (M 3)-containing compound in the presence of a lithium compound (IV) of formula LiX and a metal (M 2). R 1J 1; J 13-24C-(hetero)aryl (optionally containing B, O, N, S, Se, P or Si), linear or branched 1-20C-alkyl (optionally substituted), 2-20C-alkenyl or 2-20C-alkynyl, 3-20C-cycloalkyl (optionally substituted) or their derivatives; M 3Mn, Cu, Zn, Sn, In, La, Ce, Nd, Y, Li, Sm, Na, K, Bi, Ti, Al, Mg, B, Si or S; A : T 1; T 1halo (preferably F, Cl, Br or I), a sulfonate of formula RSO 3 - or a phosphonate of formula -OP(O)(OR) 2; R : J 1; X : T 2; T 2F, Cl, Br, CN, SCN, NCO or hal 1O k, NO 3, BF 4, PF 6, H, a carboxylate of formula RxCO 2, a disilazide of formula (Rx 3Si) 2N, a thiolate of formula SRx, an alcoholate of formula ORx, RxP(O)O 2 or SCORx, an amine of formula RxNH, a dialkyl- or diaryl amine of formula Rx 2N (preferably a cyclic alkylamine), a phosphine of formula PRx 2 (preferably a cyclic phosphine), O jSRx, NO r or their derivatives, or H; T : T 1 or T 2; Rx : 4-24C-(hetero)aryl (optionally containing B, O, N, S, Se, P or Si), linear or branched 1-20C-alkyl (optionally substituted), 2-20C-alkenyl or 2-20C-alkynyl, 3-20C-cycloalkyl (optionally substituted) or their derivatives; k : 3 or 4; hal 1Cl, Br or I; M 2Li, Na, K, Cs, Mg, Ca, Mn or Zn; j, r : 2 or 3; n : 0-3; m : 1-3; and z : greater than 0. Provided that when m is 2 or 3, then R 1 can be same or different. Independent claims are included for: (1) a process to prepare an organometallic compound (I) of formula R 1-M 1-A dzLiX comprises reacting (III) with a metal (M 1) in the presence of (IV); (2) the organometallic compound (II) (where M 3 is not Mg); (3) a solution comprising (II) in a solvent; and (4) a product obtained by the reaction of an electrophile with (II). M 1Mn, Cu, Zn, Sn, In, La, Ce, Nd, Y, Li, Sm, Na, K or Bi; and d : 0 or 1.
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机译：有机金属化合物（II）的制备包括在锂化合物（IV）和金属（M 2>）存在下使有机化合物（III）与含金属（M 3>）的化合物反应。式R 1> mM 3> -T nzLiX的有机金属化合物（II）的制备包括在锂存在下使式R 1> -A的有机化合物（III）与含金属（M 3>）的化合物反应式LiX的化合物（IV）和金属（M 2>）。 R 1> J 1>; J 1> 3-24C-（杂）芳基（可选包含B，O，N，S，Se，P或Si），直链或支链1-20C-烷基（可选取代），2-20C-烯基或2- 20C-炔基，3-20C-环烷基（任选取代的）或其衍生物; M 3＞ Mn，Cu，Zn，Sn，In，La，Ce，Nd，Y，Li，Sm，Na，K，Bi，Ti，Al，Mg，B，Si或S; A：T 1>; T 1>卤素（优选F，Cl，Br或I），式RSO 3->的磺酸盐或式-OP（O）（OR）2的膦酸酯; R：J 1>; X：T 2＞; T 2> F，Cl，Br，CN，SCN，NCO或hal 1> O k，NO 3，BF 4，PF 6，H，式RxCO 2的羧酸盐，式（Rx 3Si）2N的二硅叠氮式SRx的硫醇盐，式ORx的醇盐，RxP（O）O 2或SCORx，式RxNH的胺，式Rx 2N的二烷基或二芳基胺（最好是环状烷基胺），式PRx 2的膦优选为环状膦），O jSRx，NO r或其衍生物或H; T：T 1>或T 2>; Rx：4-24C-（杂）芳基（任选地包含B，O，N，S，Se，P或Si），直链或支链的1-20C-烷基（任选地被取代），2-20C-烯基或2-20C -炔基，3-20C-环烷基（任选取代）或它们的衍生物; k：3或4; hal 1> Cl，Br或I; M 2> Li，Na，K，Cs，Mg，Ca，Mn或Zn; j，r：2或3; n：0-3; m：1-3; z大于0。如果m为2或3，则R 1>可以相同或不同。包括以下独立权利要求：（1）制备式R 1> -M 1> -A dzLiX的有机金属化合物（I）的方法，包括在（IV）存在下使（III）与金属（M 1>）反应）; （2）有机金属化合物（II）（其中M 3>不是Mg）; （3）在溶剂中包含（II）的溶液; （4）通过亲电试剂与（II）反应获得的产物。 M 1> Mn，Cu，Zn，Sn，In，La，Ce，Nd，Y，Li，Sm，Na，K或Bi;和d：0或1。
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