Preparation of synthetic agents containing diorganomagnesium compounds and their mixtures with alkali metal salts, useful in e.g. synthetic chemistry, comprises reacting an alkali metal with a Grignard compound and an organic halo compound

摘要

Preparation of synthetic agents containing diorganomagnesium compounds and their mixtures with alkali metal salts comprises reacting alkali metal or its mixtures or alloys with Grignard compounds (a) and organic halo compounds (b). Preparation of synthetic agents containing diorganomagnesium compounds and their mixtures with alkali metal salts comprises reacting an alkali metal or its mixtures or alloys with a Grignard compound (a) of formula (RMgX) or several Grignard compounds of formulae (R 1MgX), (R 2MgX) or (R 3MgX) and an organic halo compound (b) of formula (RX) or several organic halide compounds of formulae (R 1X), (R 2X) or (R 3X). R-R 3H, optionally saturated, optionally functionalized aliphatic, cyclic, heterocyclic or aromatic 1-80C, preferably 1-20C organic fragments; and X : Cl, Br, I (all preferred), tosylate or triflate. An independent claim is included for the synthetic agent containing diorganomagensium compound of formula (R x 1R y 2Mg) as solution in an ether solvent comprising diorganomagensium compound in a mixture of lithium halo compound, Grignard compounds of formula (RMgX) and/or alkali metal organic compounds of formula (RM), where the molar ratio of the diorganomagnesium compound and lithium halo compounds is 1:0.1 to 1:2 and the molar ratio of the diorganomagnesium compound, Grignard compound and alkali metal organic compound is 1:0.15 to 1:4. x, y : 0-2 such that x+y = 2; and R-R 2CH 3, C 2H 5, iso-propyl, n-propyl, n-butyl, iso-butyl, sec.butyl, tert.butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, cyclopropyl, cyclopentyl, cyclohexyl, phenyl or benzyl.