首页>
外国专利>
Use of a rare earth metal and at least one nontoxic counterion in pharmaceutical composition for treating kidney stone
Use of a rare earth metal and at least one nontoxic counterion in pharmaceutical composition for treating kidney stone
展开▼
机译:稀土金属和至少一种无毒抗衡离子在药物组合物中用于治疗肾结石的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
A pharmaceutical composition comprises a salt of a rare earth metal (S1) and at least one nontoxic counterion (C1). (S1) Is optionally hydrated. ACTIVITY : Nephrotropic; Uropathic. MECHANISM OF ACTION : Oxalate Absorption Inhibitor. Stock sodium oxalate solution (50 ml) containing sodium chloride (8.5 g/l) was adjusted to either pH 3 or pH 7. Prior to the addition of lanthanum carbonate, a 2 ml sample was taken as a zero time point sample. The volume of buffer was made up to 50 ml, pH was adjusted and lanthanum carbonate was added so that a concentration of 0.1 M was present in the 50 ml of either pH 3 or pH 7 phosphate/oxalate buffer. A timer was started and 2 ml samples were removed at pre-determined time intervals over twenty minutes and analyzed. A phosphorus assay was performed as given in Sigma procedure 670. The results indicated that even in the presence of 10-fold excess phosphate, lanthanum carbonate bind oxalate.
展开▼