ERYTHROPOIETIN IN SUBPOLYCYTHÄMISCHEN DOSEN

摘要

Use of erythropoetin (EPO) and/or its derivatives for stimulating, in endothelial precursor cells (EPC), any of physiological mobilization; proliferation; differentiation to endothelial cells and/or migration, in the direction of an angiogenic or vasculogenic stimulus. Independent claims are also included for the following: (1) use of EPO and/or its derivatives for stimulating formation of endothelial cells (EC) and/or for vasculogenesis; (2) use of EPO to produce a transplantable EC product; (3) use of EPO for treating a tissue or organ transplant; (4) use of EPO for pretreatment of tissue or organ transplants; (5) use of EPO to prepare implantable or transplantable, cell-containing in vitro organ or tissue systems; (6) use of EPO for coating vascular prostheses or heart valves; and (7) pharmaceutical composition containing (a) EPO, its derivatives, analogs, modifications or muteins and (b) at least one of vascular endothelial growth factor, PIGF (not defined), granulocyte-macrophage colony-stimulating factor and/or a hydroxymethyl glutarate-CoA reductase inhibitor. ACTIVITY : Antilipemic; Antidiabetic; Antiinflammatory; Antiarteriosclerosis; Cardiant; Vasotropic; Antianginal; Gynecological; Hypotensive; Nephrotropic. No details of tests for any of these activities are given. MECHANISM OF ACTION : Treatment with EPO increases adhesion of EPC and stimulates formation of endothelial tissue and blood vessels.