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USE OF 1-AMINOINDANE DERIVATIVES FOR THE TREATMENT OF MANIE IN CONNECTION WITH MANIC-DEPRESSIVE DISEASE
USE OF 1-AMINOINDANE DERIVATIVES FOR THE TREATMENT OF MANIE IN CONNECTION WITH MANIC-DEPRESSIVE DISEASE
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机译:1-氨基茚满衍生物治疗躁狂抑郁症相关的躁狂症
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摘要
The subject invention provides a method of treating mania in bipolar disorder in a subject comprising administering to the subject a therapeutically effective amount of derivatives of 1-aminoindan or their racemic mixtures, enantiomers, or salts, of the general formula:wherein n is 0 or 1;each of R1 and R2 are hydrogen, C1-C4 alkyl, halogen;R3 is hydrogen, C1-C4 alkyl, hydroxy, C1-C4 alkoxy;R4 is hydrogen, C1-C4 alkyl;R6 is hydrogen, substituted or unsubstituted C1-C12 alkyl, C6-C12 aryl, C7-C12 aralkyl or A-N-R9R10, provided that R6 is not methyl when R1, R2, R3 and R4 are hydrogen atoms,wherein A is substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C6-C12 aryl, substituted or unsubstituted C7-C12 aralkyl, and each of R9 and R10 are independently hydrogen, C1-C12 alkyl, C6-C12 aryl, C7-C12 aralkyl, COOtBu, or indanyl;and racemic mixtures, enantiomers, and salts thereof.
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