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synergitische use of thiazolidinedionen and glucagon like peptide 1 and its agonists for the treatment of non insulin dependent diabetes
synergitische use of thiazolidinedionen and glucagon like peptide 1 and its agonists for the treatment of non insulin dependent diabetes
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机译:噻唑烷二酮和胰高血糖素样肽1及其激动剂在协同治疗非胰岛素依赖型糖尿病中的应用
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摘要
Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associated with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.
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