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Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof for the treatment of non-insulin-dependent diabetes
Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof for the treatment of non-insulin-dependent diabetes
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机译:噻唑烷二酮与胰高血糖素样肽-1及其激动剂协同治疗非胰岛素依赖型糖尿病
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摘要
Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associated with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.
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