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procedures for the control of the qualities of an attenuated varicella phases of vaccine
procedures for the control of the qualities of an attenuated varicella phases of vaccine
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机译:疫苗减毒水痘期质量控制程序
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摘要
Disclosed is a method for quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of the sample varicella vaccine virus conserves the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C and the 107,252nd C without suffering mutation, wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.
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机译:公开了一种用于减毒水痘活疫苗质量控制的方法,该方法包括对样品水痘疫苗病毒的基因组DNA进行序列分析,并确认样品水痘疫苗病毒的基因组DNA保守了第5,745位G,第105,356位C,第105,544 G,第106,262nd和107,252nd C个无突变,其中核苷酸编号与水痘病毒杜马斯毒株基因组DNA的SEQ ID NO:1的核苷酸序列的核苷酸编号系统一致:1。
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