CYSTONE PROTEASE INHIBITOR WITH 2-CYANO-4-AMINO-PYRIMIDINE STRUCTURE AND CATHEPSINE K-HEMDERING EFFECT FOR THE TREATMENT OF INFLAMMATION AND OTHER DISORDERS

摘要

The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g., various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.