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CYSTEINE PROTEASE INHIBITORS WITH 2-CYANO-4-AMINO-PYRIMIDINE STRUCTURE AND CATHEPSIN K INHIBITORY ACTIVITY FOR THE TREATMENT OF INFLAMMATIONS AND OTHER DISEASES
CYSTEINE PROTEASE INHIBITORS WITH 2-CYANO-4-AMINO-PYRIMIDINE STRUCTURE AND CATHEPSIN K INHIBITORY ACTIVITY FOR THE TREATMENT OF INFLAMMATIONS AND OTHER DISEASES
The invention provides compounds of formula I or a pharmaceutically acceptablesalt or ester thereof (I), wherein the symbols have meaning as defined, whichare inhibitors of cathepsin K and find use pharmaceutically for treatment ofdiseases and medical conditions in which cathepsin K is implicated, e.g.various disorders including inflammation, rheumatoid arthritis,osteoarthritis, osteoporosis and tumors.
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