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CLONING AND RECOMBINANT PREPARATION OF VESPIDENZED HYALURONIDASE AND IMMUNOLOGICAL THERAPIES BASED ON IT
CLONING AND RECOMBINANT PREPARATION OF VESPIDENZED HYALURONIDASE AND IMMUNOLOGICAL THERAPIES BASED ON IT
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机译:猪透明质酸酶的克隆,重组制备及基于它的免疫学治疗
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摘要
The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom enzymes, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase, for example, Dolichovespula maculata phospholipase and Vespula vulgaris phospholipase.
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