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Hybrid tetanus toxin proteins migrating retrograde and trans-synaptically into the CNS
Hybrid tetanus toxin proteins migrating retrograde and trans-synaptically into the CNS
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机译:杂种破伤风毒素蛋白逆行迁移并反突触进入中枢神经系统
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摘要
The non-toxic proteolytic C fragment of tetanus toxin (TTC peptide) has the same ability to bind nerve cells and be retrogradely transported through a synapse as the native toxin. A hybrid protein encoded by the lacZ-TTC gene fusion retains the biological functions of both proteins in vivo, i.e. retrograde transynaptic transport of the TTC fragment and -gal enzymatic activity. After intramuscular injection, enzymatic activity could be detected in motoneurons and connected neurons of the brainstem areas. This strategy is useful for the delivery of a biological activity to neurons from the periphery to the central nervous system. Such a hybrid protein can also be used to map synaptic connections between neural cells.
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