Method of identification of a ligand capable of modulating selectively a cascade functional involving a target and its applications for the screening a high - flow of the molecules of interest.

摘要

Process of identification of a ligand capable of selectively modulating a cascade functional involving a molecule - target or targets, as well as its applications for the screening to the top - flow rate of the molecules of interest, in particular of treatment (product) .ledit process comprises at least the following steps: a) the identification of an antibody or antibody fragment capable of binding to the target and the modulation of said cascade functional involving the said target, b) the screening from a library of molecules of the ligands modulating the connection between the target and the antibody or antibody fragment identified in a), and c) the identification on the basis of the ligands modulating obtained at b), of those capable of modulating the cascade.