METHOD FOR THE DIASTEREOSELECTIVE ALKYLATION OF NOPINONE COMPOUND OXIME ETHER AND NOVEL INTERMEDIATES FOR THE SYNTHESIS OF CARBON-SUBSTITUTED DIASTEREOSPECIFIC 2-AMINO-NOPINONE DERIVATIVES

摘要

The invention relates to a diastereoselective synthesis process .This process performs the diastereoselective alkylation of optically active nopinone for the formation of the compound of formula (I) according to scheme A below wherein: - R represents a C1-alkyl group R 1 represents, for example, a C 1 -C 15 alkyl, C 2-15 alkenyl, C 2 -C 15 alkynyl or C 5-15 aryl group; each group is optionally substituted; and X represents a halogen atom. And the compound of formula I is of either (E) or (Z) configuration, or a mixture of both. The compound of formula (I) is a valuable synthetic intermediate.