Methods for detecting neurocognitive disorders based on detecting CGG repeat expansion in the DIP2B gene

• 1. FMR1基因CGG重复数及甲基化检测试剂盒和检测方法 [P] . 中国专利： CN113151406A . 2021-07-23
• 2. 一种FMR1基因CGG重复序列的检测方法及其应用 [P] . 中国专利： CN110577987A . 2019-12-17
• 3. METHODS FOR DETECTING THE PRESENCE OF EXPANDED CGG REPEATS IN THE FMR1 GENE 5' UNTRANSLATED REGION [P] . 美国专利： US2011207153A1 . 2011-08-25

  机译： 检测FMR1基因5'非翻译区中CGG重复序列存在的方法

• 4. Methods for detecting the presence of expanded CGG repeats in the FMR1 gene 5′ untranslated region [P] . 美国专利： US8084220B2 . 2011-12-27

  机译： 检测FMR1基因5'非翻译区中扩增的CGG重复序列存在的方法

• 5. Methods for detecting the presence of expanded CGG repeats in the FMR1 gene 5′ untranslated region [P] . 美国专利： US7855053B2 . 2010-12-21

  机译： 检测FMR1基因5'非翻译区中扩增的CGG重复序列存在的方法

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• 7. CGG-Repeat Expansion in the DIP2B Gene Is Associated with the Fragile Site FRA12A on Chromosome 12q13.1 [O] . Winnepenninckx, Birgitta , Debacker, Kim , Ramsay, Jacqueline , 2007

• 1. Microarray-based method for detecting methylation changes of p16^(Ink4a) gene 5'-CpG islands in gastric carcinomas [J] . PengHou Jia-YaoShen Mei-JuJi Nong-YueHe Zu-HongLu . 世界胃肠病学杂志：英文版 . 2004,第24期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. 基于bag-of-words和Hash编码的近似重复图像检测方法 [C] . WANG Yu-Tian ,王誉天 ,QIN Hai-Quan . 2012全国高性能计算学术年会 . 2012
• 4. 环介导等温扩增技术在转基因成分筛选检测方法中的研究 [A] . 王丛 . 2015