Polypeptides capable of binding an integrin I-domain.

摘要

The present invention provides novel polypeptide comprising the amino acid sequence of SEQ ID NOS: 1, 2, 3 or 4, variants, fusions or derivatives thereof, and pharmaceutical formulations of the same. The peptides and formulations of the invention are useful for treating diseases or conditions capable of being treated by an agent which modulates the function of an integrin and/or a metzincin, such as arthritic diseases, inflammatory diseases and conditions and cancer. Also provided are diagnostic methods for such diseases and conditions, and methods of screening for candidate compounds with efficacy in the treatment of such diseases and conditions.