METHOD FOR FORMING COMPOUND HAVING INDOLE STRUCTURE FORMED BY CATALYTIC REACTION AND ITS APPLICATION IN ANTICANCER AGENT

摘要

PPROBLEM TO BE SOLVED: To provide a method for forming a compound having an indole structure formed by a catalytic reaction and the application of the compound as an anticancer agent. PSOLUTION: The forming method contains a catalytic reaction, and the catalytic reaction performs the reaction of an α,β-unsaturated ketone with indole or its derivative by using at least one kind of Lewis acid as the catalyst or the reaction of an α,β-unsaturated aldehyde with indole or its derivative by using the catalyst. The Lewis acid contains a compound selected from metal halides, halogens, inorganic ammonium chlorides and organic sulfuric acid (salts). The invention further provides an application of the compound having a 3-indole based structure as an anticancer agent. PCOPYRIGHT: (C)2008,JPO&INPIT