HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DERIVATIVE

摘要

PPROBLEM TO BE SOLVED: To provide a human monocyte chemoattractant protein-1 (MCP-1) derivative including at least one modification to the endogenous human MCP-1 and inhibiting the monocyte chemoattractant activity of the endogenous human MCP-1. PSOLUTION: The MCP-1 is modified as follows to provide the MCP-1 derivative: (a) the 28-tyrosine is substituted by aspartate; (b) the 24-arginine is substituted by phenylalanine; (c) the 3-aspartate is substituted by alanine; and/or (d) the 2-8 amino acid sequence is deleted. PCOPYRIGHT: (C)2008,JPO&INPIT