CRYSTALLINE SALT OF amp;alpha;-LIPOIC ACID AND L-LYSINE, AND METHOD FOR PREPARING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a high purity crystalline salt of α-lipoic acid and L-lysine, and an industrial method for preparing the same.;SOLUTION: The industrial method for preparing a high purity crystalline salt of α-lipoic acid and L-lysine comprises gradually dripping an aqueous ethanol solution of L-lysine of a temperature of 0 to 10°C into an ethanol solution of α-lipoic acid of a temperature of 0 to 10°C, stirring the mixed solution at the same temperature as above, isolating precipitated crystals by a commonly known method, and drying the isolated crystals at a temperature of 40°C or lower under vacuum. Thus obtained salt of α-lipoic acid and L-lysine shows a melting temperature of 149 to 151°C and shows crystallinity by X-ray diffractometry.;COPYRIGHT: (C)2008,JPO&INPIT